Joe Alaskey

Erik the Newscaster (voice)

Ken Foree

Luke St. Luke (voice)

Tom Papa

El Superbeasto (voice)

April Winchell

Dame Grace Appleton / Liza / Babs / Dolly / Joan / Gloria / Scripty / Helga Strudel (voice)

Dee Wallace

Trixie (voice)

Laraine Newman

Lefty / Kate / Courtney / Smelga Strudel / Betty Sue Lou (voice)

Cassandra Peterson

Amber (voice)

Jess Harnell

Uncle Carl (voice)

Harland Williams

Gerard the Exterminator (voice)

Rob Paulsen

Michael / Commercial Voice / Bobby Hyde / Commandant Hess / Assistant Cameraman / El Gato / Grossburger / Creature Preacher (voice)

Debra Wilson

Cigarette Girl / Bride Fronkenstein / Female Patron / Stripper in Hall / Telephone Victim / Old Woman (voice)

Tom Klein

Mr. Fly (voice)

Sheri Moon Zombie

Suzi X (voice)

Brian Posehn

Murray (voice)

Tom Kenny

Rover / Otto / Old Man / Herbie (voice)

Dee Bradley Baker

Nazi Zombie (voice)

Paul Giamatti

Dr. Satan (voice)

Geoffrey Lewis

Lenny (voice)

Rosario Dawson

Velvet Von Black (voice)

John DiMaggio

Burt the Spurt (voice)